New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments

New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments

Currently, there are no effective drugs for the treatment of amyotrophic lateral sclerosis (ALS). Only two drugs—edaravone and riluzole—have been approved, but they have very limited efficacy. The aim of this work was to modify the structural core of the Edaravone—phenylpyrazolone moiety and combine...

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Bibliographic Details
Main Authors: Maria A. Lapshina, Elena F. Shevtsova, Vladimir V. Grigoriev, Aleksey Yu. Aksinenko, Aleksey A. Ustyugov, Daniil A. Steinberg, Grigoriy V. Maleev, Elena S. Dubrovskaya, Tatiana V. Goreva, Tatiana A. Epishina, Vladimir L. Zamoyski, Galina F. Makhaeva, Vladimir P. Fisenko, Ivan M. Veselov, Daria V. Vinogradova, Sergey O. Bachurin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
amyotrophic lateral sclerosis (ALS)
edaravone
aminoadamantanes
lipid peroxidation
mitochondria
FUS protein
Online Access:https://www.mdpi.com/1420-3049/28/22/7567

Internet

https://www.mdpi.com/1420-3049/28/22/7567

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