An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors.

An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors.

Cells within a tumor microenvironment (TME) dynamically communicate and influence each other's cellular states through an intercellular communication network (ICN). In cancers, intercellular communications underlie immune evasion mechanisms of individual tumors. We developed an individualized c...

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Bibliographic Details
Main Authors: Xueer Chen, Lujia Chen, Cornelius H L Kürten, Fattaneh Jabbari, Lazar Vujanovic, Ying Ding, Binfeng Lu, Kevin Lu, Aditi Kulkarni, Tracy Tabib, Robert Lafyatis, Gregory F Cooper, Robert Ferris, Xinghua Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010761

Internet

https://doi.org/10.1371/journal.pcbi.1010761

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