Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Calpain activation has been implicated in various pathologies, including neurodegeneration. Thus, calpain inhibition could effectively prevent spinal cord injury (SCI) associated with neurodegeneration. In the current study, a dog SCI model was used to evaluate the therapeutic potential of a selecti...

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Bibliographic Details
Main Authors: Elsayed Metwally, Hatim A. Al-Abbadi, Mohamed A. Hashem, Yasmina K. Mahmoud, Eman A. Ahmed, Ahmed I. Maaty, Ibrahim E. Helal, Mahmoud F. Ahmed
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
calpain
calpain inhibitor
cBBB
dogs
methylprednisolone sodium succinate
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/23/19/11772

Internet

https://www.mdpi.com/1422-0067/23/19/11772

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