Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation

Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation

The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced sodium channel inhibition decreases the rate of cardiomyocyte depolarization and consequently conduction velocity and can have serious implicat...

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Bibliographic Details
Main Authors: Gul eErdemli, Albert M Kim, Haisong eJu, Clayton eSpringer, Robert C Penland, Peter K Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Pharmacology
Subjects:
arrhythmia
Sodium channel
ECG
preclinical
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00006/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00006/full

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