Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients

Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients

Abstract Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and non-syndromic (NS) patient...

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Bibliographic Details
Main Authors: Nicholas W. Bateman, Christopher M. Tarney, Tamara Abulez, Anthony R. Soltis, Ming Zhou, Kelly Conrads, Tracy Litzi, Julie Oliver, Brian Hood, Paul Driggers, Coralie Viollet, Clifton Dalgard, Matthew Wilkerson, William Catherino, Chad A. Hamilton, Kathleen M. Darcy, Yovanni Casablanca, Ayman Al-Hendy, James Segars, Thomas P. Conrads, G. Larry Maxwell
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88585-x

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https://doi.org/10.1038/s41598-021-88585-x

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