CCR5+ T-Cells Homed to the Liver Exhibit Inflammatory and Profibrogenic Signatures in Chronic HIV/HCV-Coinfected Patients

CCR5+ T-Cells Homed to the Liver Exhibit Inflammatory and Profibrogenic Signatures in Chronic HIV/HCV-Coinfected Patients

Liver fibrosis is accelerated in patients coinfected with hepatitis C virus and human immunodeficiency virus (HIV), compared with HCV monoinfected patients, although the underlying mechanisms are unknown. We hypothesize that T cells expressing the HIV co-receptor, chemokine receptor 5 (CCR5), prefer...

Full description

Bibliographic Details
Main Authors: Shikha Shrivastava, Shyam Kottilil, Kenneth E. Sherman, Henry Masur, Lydia Tang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
HIV
hepatitis C
fibrosis
hepatic fibrogenesis
CCR5
HIV/HCV coinfection
Online Access:https://www.mdpi.com/1999-4915/13/10/2074

Internet

https://www.mdpi.com/1999-4915/13/10/2074

Similar Items