Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process

Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process

Background: Indoleamine 2,3-dioxygenase (IDO1) and tryptophan-2,3-dioxygenase (TDO) are the two principals enzymes involved in the catabolization of tryptophan (Trp) into kynurenine (Kyn). Despite their well-established role in the immune escape, their involvement in angiogenesis remains uncertain....

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Bibliographic Details
Main Authors: Marta Cecchi, Cecilia Anceschi, Angela Silvano, Maria Luisa Coniglio, Aurora Chinnici, Lucia Magnelli, Andrea Lapucci, Anna Laurenzana, Astrid Parenti
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Pharmaceuticals
Subjects:
tryptophan 2,3-dioxygenase
angiogenesis
melanoma
kynurenine pathway
endothelial progenitor cells
endothelial cells
Online Access:https://www.mdpi.com/1424-8247/17/5/558

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https://www.mdpi.com/1424-8247/17/5/558

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