Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers

Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers

Mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors show limited benefit in Kirsten rat sarcoma (<i>KRAS</i>) mutant pancreatic cancer due to drug resistance. To identify mechanisms of resistance to MEK inhibitor (MEKi), we employed a differential expression analysis of MEKi-...

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Bibliographic Details
Main Authors: Boya Li, Yu Feng, Qiaoyun Hou, Yan Fu, Yongzhang Luo
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
TAP1
ABCB2
MEK inhibitor
drug resistance
PDAC
Online Access:https://www.mdpi.com/1422-0067/23/13/7168

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https://www.mdpi.com/1422-0067/23/13/7168

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