RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27

RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27

Multiple myeloma (MM) is a clonal disease of plasma cells that remains, for the most part, incurable despite the advent of several novel therapeutics. The elevated expression of p27 and its association with cell-cycle arrest is speculated to be one of the major mechanisms by which MM cells escape th...

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Bibliographic Details
Main Authors: Enfang Bao, Yu Zhou, Song He, Jie Tang, Yunhua He, Mengyuan Zhu, Chun Cheng, Yuchan Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Cancer Biology & Therapy
Subjects:
ring box-1
p27
multiple myeloma
drug resistance
bone marrow
f-box protein
Online Access:http://dx.doi.org/10.1080/15384047.2023.2231670

Internet

http://dx.doi.org/10.1080/15384047.2023.2231670

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