Metabolic Regulation of Hematopoietic Stem Cells
Cellular metabolism is a key regulator of hematopoietic stem cell (HSC) maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. However, increasing eviden...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | HemaSphere |
| Online Access: | http://journals.lww.com/10.1097/HS9.0000000000000740 |
| _version_ | 1827332065077493760 |
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| author | Claudia Morganti Nina Cabezas-Wallscheid Keisuke Ito |
| author_facet | Claudia Morganti Nina Cabezas-Wallscheid Keisuke Ito |
| author_sort | Claudia Morganti |
| collection | DOAJ |
| description | Cellular metabolism is a key regulator of hematopoietic stem cell (HSC) maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. However, increasing evidence has shown that HSCs still maintain a certain level of mitochondrial activity in quiescence, and exhibit high mitochondrial membrane potential, which both support proper HSC function. Since glycolysis and the tricarboxylic acid (TCA) cycle are not directly connected in HSCs, other nutrient pathways, such as amino acid and fatty acid metabolism, generate acetyl-CoA and provide it to the TCA cycle. In this review, we discuss recent insights into the regulatory roles of cellular metabolism in HSCs. Understanding the metabolic requirements of healthy HSCs is of critical importance to the development of new therapies for hematological disorders. |
| first_indexed | 2024-03-07T16:52:26Z |
| format | Article |
| id | doaj.art-c02f5a90eb634c31a9f33202ef0629a5 |
| institution | Directory Open Access Journal |
| issn | 2572-9241 |
| language | English |
| last_indexed | 2024-03-07T16:52:26Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | HemaSphere |
| spelling | doaj.art-c02f5a90eb634c31a9f33202ef0629a52024-03-03T04:41:57ZengWileyHemaSphere2572-92412022-07-0167e74010.1097/HS9.0000000000000740202207000-00009Metabolic Regulation of Hematopoietic Stem CellsClaudia Morganti0Nina Cabezas-Wallscheid1Keisuke Ito21 Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA4 Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany1 Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USACellular metabolism is a key regulator of hematopoietic stem cell (HSC) maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. However, increasing evidence has shown that HSCs still maintain a certain level of mitochondrial activity in quiescence, and exhibit high mitochondrial membrane potential, which both support proper HSC function. Since glycolysis and the tricarboxylic acid (TCA) cycle are not directly connected in HSCs, other nutrient pathways, such as amino acid and fatty acid metabolism, generate acetyl-CoA and provide it to the TCA cycle. In this review, we discuss recent insights into the regulatory roles of cellular metabolism in HSCs. Understanding the metabolic requirements of healthy HSCs is of critical importance to the development of new therapies for hematological disorders.http://journals.lww.com/10.1097/HS9.0000000000000740 |
| spellingShingle | Claudia Morganti Nina Cabezas-Wallscheid Keisuke Ito Metabolic Regulation of Hematopoietic Stem Cells HemaSphere |
| title | Metabolic Regulation of Hematopoietic Stem Cells |
| title_full | Metabolic Regulation of Hematopoietic Stem Cells |
| title_fullStr | Metabolic Regulation of Hematopoietic Stem Cells |
| title_full_unstemmed | Metabolic Regulation of Hematopoietic Stem Cells |
| title_short | Metabolic Regulation of Hematopoietic Stem Cells |
| title_sort | metabolic regulation of hematopoietic stem cells |
| url | http://journals.lww.com/10.1097/HS9.0000000000000740 |
| work_keys_str_mv | AT claudiamorganti metabolicregulationofhematopoieticstemcells AT ninacabezaswallscheid metabolicregulationofhematopoieticstemcells AT keisukeito metabolicregulationofhematopoieticstemcells |