Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting

Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting

Abstract Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in skeletal muscle are partly regulated by histidyl dip...

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Bibliographic Details
Main Authors: Dheeraj Kumar Posa, Janice Miller, David Hoetker, Michael I. Ramage, Hong Gao, Jingjing Zhao, Benjamin Doelling, Aruni Bhatnagar, Stephen J. Wigmore, Richard J.E. Skipworth, Shahid P. Baba
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Anserine
Beta‐alanine
Histidyl dipeptides
Lipid peroxidation products
Ubiquitin
Online Access:https://doi.org/10.1002/jcsm.13258

Internet

https://doi.org/10.1002/jcsm.13258

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