Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

ABSTRACT Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti-inflammatory cytokine interleukin 10 (IL-10) during...

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Bibliographic Details
Main Authors: Heather M. Evans, Destiny F. Schultz, Adam J. Boiman, Melanie C. McKell, Joseph E. Qualls, George S. Deepe
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:mBio
Subjects:
Histoplasma
hypoxia inducible factor 1
lung
innate immunity
mitochondrial metabolism
Online Access:https://journals.asm.org/doi/10.1128/mBio.02710-21

Internet

https://journals.asm.org/doi/10.1128/mBio.02710-21

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