Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action

Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substitute...

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Bibliographic Details
Main Authors: Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
lipophilicity
1,9-diazaphenothiazines
anticancer action
ADME
Lipinski’s rule of five
Ghose’s and Veber’s rules
Online Access:https://www.mdpi.com/1422-0067/24/8/6970

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https://www.mdpi.com/1422-0067/24/8/6970

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