Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages

Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages

Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation. PDE activity and expression are linked to many diseases including inflammatory diseases. In light of their s...

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Bibliographic Details
Main Authors: Simona Todisco, Vittoria Infantino, Anna Caruso, Anna Santarsiero, Paolo Convertini, Hussein El-Kashef, Federica Giuzio, Maria Stefania Sinicropi, Carmela Saturnino
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Applied Sciences
Subjects:
indole
carbazole
purine
PDE4B
inhibitors
macrophage activation
Online Access:https://www.mdpi.com/2076-3417/14/15/6747

Internet

https://www.mdpi.com/2076-3417/14/15/6747

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