A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits

A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits

Ketamine exposure can model cognitive deficits associated with schizophrenia. Progesterone (PROG) and its active metabolite allopregnanolone (ALLO) have neuroprotective effects and the pathway involving progesterone receptor membrane component 1 (PGRMC1), epidermal growth factor receptor (EGFR), glu...

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Bibliographic Details
Main Authors: Ting Cao, MiMi Tang, Pei Jiang, BiKui Zhang, XiangXin Wu, Qian Chen, CuiRong Zeng, NaNa Li, ShuangYang Zhang, HuaLin Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
cognitive deficits
neuroprotection
PGRMC1 signaling
progesterone
allopregnanolone
ketamine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.612083/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.612083/full

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