Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis

Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis

Sepsis, the leading cause of death in intensive care units, is associated with overproduction of nitric oxide (NO) due to inducible NO synthase (iNOS), responsible for some of the pathologic changes. Aminoguanidine (AG) is a selective iNOS inhibitor with reported inconsistent actions in sepsis. To i...

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Bibliographic Details
Main Authors: R.S. Astolfi, D.G. Khouri, L.I.V. Brandizzi, M.J. Ávila-Campos, H.F. de Andrade Jr.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2007-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Nitric oxide
Sepsis
Experimental model
Bacterial infections
Escherichia coli
Bacteroides fragilis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300006

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