Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma

Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma

Abstract Background Hypoxia inducible factors, HIF‐1α and HIF‐2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to hypoxia and contribute to tumor progression in clear cell renal cell carcinoma (ccRCC). These biomarkers may improve the value of t...

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Bibliographic Details
Main Authors: Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Cancer Medicine
Subjects:
biomarker
hydroxylase‐domain proteins (PHD)
hypoxia inducible factors (HIF)
recurrence‐free survival
renal cell carcinoma (RCC)
Online Access:https://doi.org/10.1002/cam4.6998

Internet

https://doi.org/10.1002/cam4.6998

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