Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy

Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy

Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied. A new transgenic animal model producing an excess of bradykinin by proximal tubu...

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Bibliographic Details
Main Authors: Carlos C. Barros, Ines Schadock, Gabin Sihn, Franziska Rother, Ping Xu, Elena Popova, Irina Lapidus, Ralph Plehm, Arnd Heuser, Mihail Todiras, Sebastian Bachmann, Natalia Alenina, Ronaldo C. Araujo, Joao B. Pesquero, Michael Bader
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Medicine
Subjects:
kinin
kallikrein-kinin system
blood pressure
polyuria
rats
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00338/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00338/full

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