Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing.

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing.

Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of the splicing machinery that are crucial for exon se...

Full description

Bibliographic Details
Main Authors: Shinsuke Araki, Ryo Dairiki, Yusuke Nakayama, Aiko Murai, Risa Miyashita, Misa Iwatani, Toshiyuki Nomura, Osamu Nakanishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4291223?pdf=render

Internet

http://europepmc.org/articles/PMC4291223?pdf=render

Similar Items