Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.

Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.

Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism. To dissect the role of parathyroid gland resident Klotho in health and disease,...

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Bibliographic Details
Main Authors: Hannes Olauson, Karolina Lindberg, Risul Amin, Tadatoshi Sato, Ting Jia, Regina Goetz, Moosa Mohammadi, Göran Andersson, Beate Lanske, Tobias E Larsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3861040?pdf=render

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http://europepmc.org/articles/PMC3861040?pdf=render

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