Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression

Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression

<i>Background:</i> Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in human breast cancer. However, the cell type-specific Ctsl functions responsible for this association remain elu...

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Bibliographic Details
Main Authors: María Alejandra Parigiani, Anett Ketscher, Sylvia Timme, Peter Bronsert, Manuel Schlimpert, Bernd Kammerer, Arnaud Jacquel, Paul Chaintreuil, Thomas Reinheckel
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
breast cancer
lysosome
proteolysis
genetically engineered mice
Online Access:https://www.mdpi.com/2072-6694/12/8/2004

Internet

https://www.mdpi.com/2072-6694/12/8/2004

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