MicroRNA‐34a‐Dependent Attenuation of Angiogenesis in Right Ventricular Failure

MicroRNA‐34a‐Dependent Attenuation of Angiogenesis in Right Ventricular Failure

Background The right ventricle (RV) is at risk in patients with complex congenital heart disease involving right‐sided obstructive lesions. We have shown that capillary rarefaction occurs early in the pressure‐loaded RV. Here we test the hypothesis that microRNA (miR)‐34a, which is induced in RV hyp...

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Bibliographic Details
Main Authors: Sushma Reddy, Dong‐Qing Hu, Mingming Zhao, Shoko Ichimura, Elizabeth A. Barnes, David N. Cornfield, Miguel A. Alejandre Alcázar, Edda Spiekerkoetter, Giovanni Fajardo, Daniel Bernstein
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis
congenital heart disease
fibroblasts
heart failure
microRNA
right ventricle
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.029427

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https://www.ahajournals.org/doi/10.1161/JAHA.123.029427

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