Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis

Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis

IntroductionOptic neuritis (ON) is often an early sign of multiple sclerosis (MS), and recent studies show a link between HIF-1 pathway activation and inflammation. This study aimed to determine if inhibition of the HIF-1 pathway using the HIF-1a antagonist acriflavine (ACF) can reduce clinical prog...

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Bibliographic Details
Main Authors: Jeffrey J. Anders, Benjamin W. Elwood, Randy H. Kardon, Oliver W. Gramlich
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
EAE
optic neuritis
multiple sclerosis
retinal ganglion cells
acriflavine
HIF-1 inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271118/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271118/full

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