The ‘New (Nu)-clear’ evidence of the tumor-driving role of PI3K
The classical phosphatidylinositol 3-kinases (PI3Ks) are heterodimers of p110 and p85. PIK3CA, the gene encoding the catalytic p110α subunit, is one of the most frequently mutated oncogenes in human cancers. Mutations have been observed to occur in hotspots in the helical domain or kinase domain. Tu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2022-05-01
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| Series: | Acta Materia Medica |
| Subjects: | |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0013 |