Tetracyclic triterpenoids as inhibitors of cytochrome P450 3A4 and their quantitative structure activity relationship analysis

Tetracyclic triterpenoids as inhibitors of cytochrome P450 3A4 and their quantitative structure activity relationship analysis

The interaction between herbs and clinical drugs is one of the risk factors for adverse drug reactions. In the present study, the inhibitory effects of 47 tetracyclic triterpenoids toward the main drug-metabolizing CYPs in humans were investigated. Most of the evaluated tetracyclic triterpenoids (TT...

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Bibliographic Details
Main Authors: Wei Pan, Lei Feng, Cheng-Peng Sun, Xiang-Ge Tian, Chao Shi, Chao Wang, Xia Lv, Yan Wang, Shan-Shan Huang, Bao-Jing Zhang, Jing Ning, Xiao-Chi Ma
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Arabian Journal of Chemistry
Subjects:
Tetracyclic triterpenoids
Cytochrome P450 3A4
Structure-activity relationship
Herbal-drug interactions
Inhibition mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223006184

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http://www.sciencedirect.com/science/article/pii/S1878535223006184

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