Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and phosphorylation of several proteins involved in the ph...

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Bibliographic Details
Main Authors: CRISTIANA S.B. SALVATIERRA, SÍLVIA R.L. REIS, ANA F.M. PESSOA, LETÍCIA M.I. DE SOUZA, LUIZ F. STOPPIGLIA, ROBERTO V. VELOSO, MARISE A.B. REIS, EVERARDO M. CARNEIRO, ANTONIO C. BOSCHERO, EDSON M. COLODEL, VANESSA C. ARANTES, MÁRCIA Q. LATORRACA
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2015-06-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
via da MAP-cinase
ilhotas pancreáticas
via da PI3-cinase
prenhez
restrição de proteína
ratos
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201007&lng=en&tlng=en

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