KCC2 function modulates in vitro ictogenesis

GABAA receptor-mediated inhibition is active and may contribute to epileptiform synchronization. The efficacy of inhibition relies on low levels of intracellular Cl−, which are controlled by KCC2 activity. This evidence has led us to analyze with field potential recordings the effects induced by the...

Full description

Bibliographic Details
Main Authors: Shabnam Hamidi, Massimo Avoli
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001539