Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion

Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion

Genetic prion disease accounts for 10–15% of prion disease. While insertion of four or more octapeptide repeats are clearly pathogenic, smaller repeat insertions have an unclear pathogenicity. The goal of this case series was to provide an insight into the characteristics of the 2-octapeptide repeat...

Full description

Bibliographic Details
Main Authors: Nicholas Brennecke, Ignazio Cali, Tze How Mok, Helen Speedy, Genomics England Research Consortium, Laszlo L. P. Hosszu, Christiane Stehmann, Laura Cracco, Gianfranco Puoti, Thomas W. Prior, Mark L. Cohen, Steven J. Collins, Simon Mead, Brian S. Appleby
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
prion disease
Creutzfeldt-Jakob disease
genetic Creutzfeldt-Jakob disease
genetics
octapeptide repeat insertion
Online Access:https://www.mdpi.com/1999-4915/13/9/1794

Internet

https://www.mdpi.com/1999-4915/13/9/1794

Similar Items