Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma

Abstract Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. It is known that the tumor microenvironment (TME) regulates tumorigenesis and metastasis. However, how the malignant progression in RB is determined by the heterogeneity of tumor cells and TME remains unchar...

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Bibliographic Details
Main Authors: Cheng Wu, Jiaqi Yang, Wei Xiao, Zehang Jiang, Shuxia Chen, Dianlei Guo, Ping Zhang, Chunqiao Liu, Huasheng Yang, Zhi Xie
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04904-8