The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryonic development and cancer. Here, we show that a mac...

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Bibliographic Details
Main Authors: Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
Wnt signaling
macropinocytosis
lysosomes
colorectal cancer
β-catenin
Online Access:https://elifesciences.org/articles/89141

Internet

https://elifesciences.org/articles/89141

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