Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

Summary: Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ultrastructure in dorsolateral prefrontal cortex (dlPFC...

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Bibliographic Details
Main Authors: Tristan Fehr, William G.M. Janssen, Janis Park, Mark G. Baxter
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019587