The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

Abstract Background Lung cancer is one of the fatal cancers worldwide, and over 60% of patients are lung adenocarcinoma (LUAD). Our clinical data demonstrated that DNA methylation of the promoter region of miR-126-3p was upregulated, which led to the decreased expression of miR-126-3p in 67 cases of...

Full description

Bibliographic Details
Main Authors: Lu Liang, Huiyu Cen, Jionghua Huang, Aiping Qin, Wenyan Xu, Siran Wang, Zhijun Chen, Lin Tan, Qiqi Zhang, Xiyong Yu, Xin Yang, Lingmin Zhang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Cancer
Subjects:
Biomimetic nanoparticles
Lung adenocarcinoma
MicroRNA
MMP2
DNA methylation
Online Access:https://doi.org/10.1186/s12943-022-01651-4

Internet

https://doi.org/10.1186/s12943-022-01651-4

Similar Items