Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Abstract Background Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate cells (PSCs) of the tumor stroma are known to interact with pancreatic c...

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Bibliographic Details
Main Authors: Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke, Ivar P. Gladhaug
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Pancreatic stellate cells
Gemcitabine
Fibronectin
Pancreatic cancer
Chemoresistance
Extracellular matrix
Online Access:http://link.springer.com/article/10.1186/s12885-019-5803-1

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http://link.springer.com/article/10.1186/s12885-019-5803-1

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