Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload

Abstract Nearly 1 in every 100 children born have a congenital heart defect. Many of these defects primarily affect the right heart causing pressure overload of the right ventricle (RV). The RV maintains function by adapting to the increased pressure; however, many of these adaptations eventually le...

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Bibliographic Details
Main Authors: Vidhya Prasad, Nour Makkaoui, Rohan Rajan, Alisha Patel, Bipul Mainali, Pritha Bagchi, Rhea Kumar, Julia Rogers, Jake Diamond, Joshua T. Maxwell
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.15238