Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer

Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer

The present study was carried out to investigate the potential of cationic functionalization on imatinib nanocrystals to improve the mucoadhesiveness and, thus, delivery to the lesion of cervicovaginal tumors. Amino-group-functionalized imatinib nanocrystals (NC@PDA-NH2) were prepared with near-sphe...

Full description

Bibliographic Details
Main Authors: Li-qian Ci, Zhi-gang Huang, Feng-mei Lv, Jun Wang, Ling-lin Feng, Feng Sun, Shui-juan Cao, Zhe-peng Liu, Yu Liu, Gang Wei, Wei-yue Lu
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
mucoadhesiveness
cervicovaginal tumors
cationic functionalization
imatinib
nanocrystals
in situ hydrogel
Online Access:http://www.mdpi.com/1999-4923/11/1/15

Internet

http://www.mdpi.com/1999-4923/11/1/15

Similar Items