Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histological biomarkers

Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histological biomarkers

Abstract We investigated the associations of time-dependent DWI, non-Gaussian DWI, and CEST parameters with histological biomarkers in a breast cancer xenograft model. 22 xenograft mice (7 MCF-7 and 15 MDA-MB-231) were scanned at 4 diffusion times [Td = 2.5/5 ms with 11 b-values (0–600 s/mm2) and Td...

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Bibliographic Details
Main Authors: Yuko Someya, Mami Iima, Hirohiko Imai, Akihiko Yoshizawa, Masako Kataoka, Hiroyoshi Isoda, Denis Le Bihan, Yuji Nakamoto
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10081-7

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https://doi.org/10.1038/s41598-022-10081-7

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