Dual analysis of wild-type and attenuated Orf virus and host cell transcriptomes revealed novel virus-host cell interactions

Dual analysis of wild-type and attenuated Orf virus and host cell transcriptomes revealed novel virus-host cell interactions

ABSTRACTThe attenuated Orf virus (ORFV) strain (aFX0910), derived from continuous passages of wild-type strain FX0910 in vitro, displays obviously lower virulence in kids. However, the latent virulence determinants and intracellular mechanisms for the attenuated variant remain unknown. In this study...

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Bibliographic Details
Main Authors: Xiaoting Yao, Tian Jing, Qingru Geng, Ming Pang, Xuanduo Zhao, Shaofei Li, Dekun Chen, Wentao Ma
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mSphere
Subjects:
Orf virus
dual RNA sequencing
viral transcriptome
virulence determinant
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/msphere.00398-23

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https://journals.asm.org/doi/10.1128/msphere.00398-23

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