Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics

Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics

Human coronaviruses like MERS CoV are known to utilize dipeptidyl peptidase 4 (DPP4), apart from angiotensin-converting enzyme 2(ACE2) as a potential co-receptor for viral cell entry. DPP4, the ubiquitous membrane-bound aminopeptidase, is closely associated with elevation of disease severity in como...

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Bibliographic Details
Main Authors: Arpan Narayan Roy, Aayatti Mallick Gupta, Deboshmita Banerjee, Jaydeb Chakrabarti, Pongali B. Raghavendra
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
MERS-CoV
DPP4
SARS-CoV-2
RBD
spike protein variants
binding affinity
Online Access:https://www.mdpi.com/1999-4915/15/10/2056

Internet

https://www.mdpi.com/1999-4915/15/10/2056

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