Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice.

Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice.

High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether mitochondrial dysfunction is a direct effect of a HFD, or if mitochondrial function is reduced with...

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Bibliographic Details
Main Authors: Natalie C Sadler, Thomas E Angel, Michael P Lewis, Leeanna M Pederson, Lacie M Chauvigné-Hines, Susan D Wiedner, Erika M Zink, Richard D Smith, Aaron T Wright
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480472?pdf=render

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http://europepmc.org/articles/PMC3480472?pdf=render

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