Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different s...

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Bibliographic Details
Main Authors: Donglu Zhang, Gang Luo, Xinxin Ding, Chuang Lu
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Preclinical
In vitro model
Drug metabolism and disposition
ADME
Engineered mouse model
Caco-2
Hepatocytes
Mass balance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512001438

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http://www.sciencedirect.com/science/article/pii/S2211383512001438

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