SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes

SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes

Abstract Although an increased risk of myocarditis has been observed after vaccination with mRNA encoding severe acute respiratory syndrome coronavirus 2 spike protein, its underlying mechanism has not been elucidated. This study investigated the direct effects of spike receptor-binding domain (S-RB...

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Bibliographic Details
Main Authors: Shota Okuno, Shuichiro Higo, Takumi Kondo, Mikio Shiba, Satoshi Kameda, Hiroyuki Inoue, Tomoka Tabata, Shou Ogawa, Yu Morishita, Congcong Sun, Saki Ishino, Tomoyuki Honda, Shigeru Miyagawa, Yasushi Sakata
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48084-7

Internet

https://doi.org/10.1038/s41598-023-48084-7

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