Stem cell models of Angelman syndrome

Stem cell models of Angelman syndrome

Angelman syndrome (AS) is an imprinted neurodevelopmental disorder that lacks a cure, characterized by developmental delay, intellectual impairment, seizures, ataxia, and paroxysmal laughter. The condition arises due to the loss of the maternally inherited copy of the UBE3A gene in neurons. The pate...

Full description

Bibliographic Details
Main Authors: João Camões dos Santos, Carolina Appleton, Francisca Cazaux Mateus, Rita Covas, Evguenia Pavlovna Bekman, Simão Teixeira da Rocha
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Angelman syndrome (AS)
genomic imprinting
UBE3A
pluripotent stem cells (PSCs)
disease modeling
brain organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1274040/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1274040/full

Similar Items