Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)–P couplings. The antiproliferative activities of the newly synthesised brominated and phosphonated compounds against a panel of hum...

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Bibliographic Details
Main Authors: Rebeka Jójárt, Seyyed Ashkan Senobar Tahaei, Péter Trungel-Nagy, Zoltán Kele, Renáta Minorics, Gábor Paragi, István Zupkó, Erzsébet Mernyák
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
hirao reaction
azide–alkyne cycloaddition
antiproliferative effect
tubulin polymerisation
molecular dynamics
Online Access:http://dx.doi.org/10.1080/14756366.2020.1838500

Internet

http://dx.doi.org/10.1080/14756366.2020.1838500

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