Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

Summary: Centriolar satellites are high-order assemblies, scaffolded by the protein PCM1, that gravitate as particles around the centrosome and play pivotal roles in fundamental cellular processes notably ciliogenesis and autophagy. Despite stringent control mechanisms involving phosphorylation and...

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Bibliographic Details
Main Authors: Clotilde C.N. Renaud, Carolina Alves Nicolau, Clément Maghe, Kilian Trillet, Jane Jardine, Sophie Escot, Nicolas David, Julie Gavard, Nicolas Bidère
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008022

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224008022

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