Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR

Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR

Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a key pathophysiological component of airway remodeling in chronic obstructive pulmonary disease (COPD) for which pharmacotherapy is limited, and only slight improvements in survival have been achieved in recent de...

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Bibliographic Details
Main Authors: Wei Hong, Gongyong Peng, Binwei Hao, Baoling Liao, Zhuxiang Zhao, Yumin Zhou, Fang Peng, Xiuqin Ye, Lingmei Huang, Mengning Zheng, Jinding Pu, Chunxiao Liang, Erkang Yi, Huanhuan Peng, Bing Li, Pixin Ran
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
chronic obstructive pulmonary disease
Store-operated calcium entry
Receptor-operated calcium entry
Canonical transient receptor potential protein 6
α7 nAChR
Online Access:https://www.karger.com/Article/FullText/481651

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https://www.karger.com/Article/FullText/481651

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