Emerging role of different DNA methyltransferases in the pathogenesis of cancer
DNA methylation is one of the most essential epigenetic mechanisms to regulate gene expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the genome. In mammals, DNMTs act with some elements to regulate the dynamic DNA methylation patterns of embryonic and adult cells. C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.958146/full |
| _version_ | 1828355929941213184 |
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| author | Pengcheng Liu Fan Yang Lizhi Zhang Ying Hu Bangjie Chen Jianpeng Wang Lei Su Mingyue Wu Wenjian Chen |
| author_facet | Pengcheng Liu Fan Yang Lizhi Zhang Ying Hu Bangjie Chen Jianpeng Wang Lei Su Mingyue Wu Wenjian Chen |
| author_sort | Pengcheng Liu |
| collection | DOAJ |
| description | DNA methylation is one of the most essential epigenetic mechanisms to regulate gene expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the genome. In mammals, DNMTs act with some elements to regulate the dynamic DNA methylation patterns of embryonic and adult cells. Conversely, the aberrant function of DNMTs is frequently the hallmark in judging cancer, including total hypomethylation and partial hypermethylation of tumor suppressor genes (TSGs), which improve the malignancy of tumors, aggravate the ailment for patients, and significantly exacerbate the difficulty of cancer therapy. Since DNA methylation is reversible, currently, DNMTs are viewed as an important epigenetic target for drug development. However, the impression of DNMTs on cancers is still controversial, and therapeutic methods targeting DNMTs remain under exploration. This review mainly summarizes the relationship between the main DNMTs and cancers as well as regulatory mechanisms and clinical applications of DNMTs in cancer and highlights several forthcoming strategies for targeting DNMTs. |
| first_indexed | 2024-04-14T02:50:36Z |
| format | Article |
| id | doaj.art-c07d13946eab4436ae431ce52d379874 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-14T02:50:36Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-c07d13946eab4436ae431ce52d3798742022-12-22T02:16:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.958146958146Emerging role of different DNA methyltransferases in the pathogenesis of cancerPengcheng Liu0Fan Yang1Lizhi Zhang2Ying Hu3Bangjie Chen4Jianpeng Wang5Lei Su6Mingyue Wu7Wenjian Chen8Department of Human Resources, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaThe First Clinical Medical College, Anhui Medical University, Hefei, ChinaThe First Clinical Medical College, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaThe First Clinical Medical College, Anhui Medical University, Hefei, ChinaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Orthopaedics, Anhui Provincial Children’s Hospital, Hefei, ChinaDNA methylation is one of the most essential epigenetic mechanisms to regulate gene expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the genome. In mammals, DNMTs act with some elements to regulate the dynamic DNA methylation patterns of embryonic and adult cells. Conversely, the aberrant function of DNMTs is frequently the hallmark in judging cancer, including total hypomethylation and partial hypermethylation of tumor suppressor genes (TSGs), which improve the malignancy of tumors, aggravate the ailment for patients, and significantly exacerbate the difficulty of cancer therapy. Since DNA methylation is reversible, currently, DNMTs are viewed as an important epigenetic target for drug development. However, the impression of DNMTs on cancers is still controversial, and therapeutic methods targeting DNMTs remain under exploration. This review mainly summarizes the relationship between the main DNMTs and cancers as well as regulatory mechanisms and clinical applications of DNMTs in cancer and highlights several forthcoming strategies for targeting DNMTs.https://www.frontiersin.org/articles/10.3389/fphar.2022.958146/fullDNMTcancercellular signaling pathwaysepigeneticsanticancer therapy |
| spellingShingle | Pengcheng Liu Fan Yang Lizhi Zhang Ying Hu Bangjie Chen Jianpeng Wang Lei Su Mingyue Wu Wenjian Chen Emerging role of different DNA methyltransferases in the pathogenesis of cancer Frontiers in Pharmacology DNMT cancer cellular signaling pathways epigenetics anticancer therapy |
| title | Emerging role of different DNA methyltransferases in the pathogenesis of cancer |
| title_full | Emerging role of different DNA methyltransferases in the pathogenesis of cancer |
| title_fullStr | Emerging role of different DNA methyltransferases in the pathogenesis of cancer |
| title_full_unstemmed | Emerging role of different DNA methyltransferases in the pathogenesis of cancer |
| title_short | Emerging role of different DNA methyltransferases in the pathogenesis of cancer |
| title_sort | emerging role of different dna methyltransferases in the pathogenesis of cancer |
| topic | DNMT cancer cellular signaling pathways epigenetics anticancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.958146/full |
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