A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation

Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond si...

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Bibliographic Details
Main Authors: Jeannette Reinig, Frank Ruge, Martin Howard, Leonie Ringrose
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18507-4