A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation
Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond si...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18507-4 |
| _version_ | 1828972504398430208 |
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| author | Jeannette Reinig Frank Ruge Martin Howard Leonie Ringrose |
| author_facet | Jeannette Reinig Frank Ruge Martin Howard Leonie Ringrose |
| author_sort | Jeannette Reinig |
| collection | DOAJ |
| description | Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond simple epigenetic memory. |
| first_indexed | 2024-12-14T13:29:10Z |
| format | Article |
| id | doaj.art-c081d1c5a15a439ca97b4307c27e34a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:29:10Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c081d1c5a15a439ca97b4307c27e34a72022-12-21T22:59:45ZengNature PortfolioNature Communications2041-17232020-09-0111111610.1038/s41467-020-18507-4A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulationJeannette Reinig0Frank Ruge1Martin Howard2Leonie Ringrose3Humboldt Universität zu Berlin, IRI- LifesciencesIMBA, Institute of Molecular BiotechnologyJohn Innes Centre, Norwich Research ParkHumboldt Universität zu Berlin, IRI- LifesciencesPolycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond simple epigenetic memory.https://doi.org/10.1038/s41467-020-18507-4 |
| spellingShingle | Jeannette Reinig Frank Ruge Martin Howard Leonie Ringrose A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation Nature Communications |
| title | A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation |
| title_full | A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation |
| title_fullStr | A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation |
| title_full_unstemmed | A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation |
| title_short | A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation |
| title_sort | theoretical model of polycomb trithorax action unites stable epigenetic memory and dynamic regulation |
| url | https://doi.org/10.1038/s41467-020-18507-4 |
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