Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension

Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension

IntroductionMild traumatic brain injury (mTBI) and hypertension synergize to induce persistent disruption of the blood–brain barrier (BBB), neuroinflammation and cognitive decline. However, the underlying mechanisms are not known. Cerebral production of Cyclophilin A (CyPA) is induced in hypertensio...

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Bibliographic Details
Main Authors: Dominika Lendvai-Emmert, Zsofia Dina Magyar-Sumegi, Emoke Hegedus, Nikolett Szarka, Balint Fazekas, Krisztina Amrein, Endre Czeiter, Andras Buki, Zoltan Ungvari, Peter Toth
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Neurology
Subjects:
mTBI
hypertension
BBB
CyPA
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1252796/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1252796/full

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