Effects of Trehalose on Thermodynamic Properties of Alpha-synuclein Revealed through Synchrotron Radiation Circular Dichroism

Many neurodegenerative diseases, including Huntington’s, Alzheimer’s and Parkinson’s diseases, are characterized by protein misfolding and aggregation. The capability of trehalose to interfere with protein misfolding and aggregation has been recently evaluated by several research groups. In the pres...

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Bibliographic Details
Main Authors: Paolo Ruzza, Rohanah Hussain, Barbara Biondi, Andrea Calderan, Isabella Tessari, Luigi Bubacco, Giuliano Siligardi
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/5/2/724